Study Suggests Lower Death Risk for the Overweight





A century ago, Elsie Scheel was the perfect woman. So said a 1912 article in The New York Times about how Miss Scheel, 24, was chosen by the “medical examiner of the 400 'co-eds'” at Cornell University as a woman “whose very presence bespeaks perfect health.”




Miss Scheel, however, was hardly model-thin. At 5-foot-7 and 171 pounds, she would, by today's medical standards, be clearly overweight. (Her body mass index was 27; 25 to 29.9 is overweight.)


But a new report suggests that Miss Scheel may have been onto something. The report on nearly three million people found that those whose B.M.I. ranked them as overweight had less risk of dying than people of normal weight. And while obese people had a greater mortality risk over all, those at the lowest obesity level (B.M.I. of 30 to 34.9) were not more likely to die than normal-weight people.


The report, although not the first to suggest this relationship between B.M.I. and mortality, is by far the largest and most carefully done, analyzing nearly 100 studies, experts said.


But don’t scrap those New Year’s weight-loss resolutions and start gorging on fried Belgian waffles or triple cheeseburgers.


Experts not involved in the research said it suggested that overweight people need not panic unless they have other indicators of poor health and that depending on where fat is in the body, it might be protective or even nutritional for older or sicker people. But over all, piling on pounds and becoming more than slightly obese remains dangerous.


“We wouldn’t want people to think, ‘Well, I can take a pass and gain more weight,'” said Dr. George Blackburn, associate director of Harvard Medical School’s nutrition division.


Rather, he and others said, the report, in The Journal of the American Medical Association, suggests that B.M.I., a ratio of height to weight, should not be the only indicator of healthy weight.


“Body mass index is an imperfect measure of the risk of mortality,” and factors like blood pressure, cholesterol and blood sugar must be considered, said Dr. Samuel Klein, director of the Center for Human Nutrition at Washington University School of Medicine in St. Louis.


Dr. Steven Heymsfield, executive director of the Pennington Biomedical Research Center in Louisiana, who wrote an editorial accompanying the study, said that for overweight people, if indicators like cholesterol “are in the abnormal range, then that weight is affecting you,” but that if indicators are normal, there’s no reason to “go on a crash diet.”


Experts also said the data suggested that the definition of "normal" B.M.I., 18.5 to 24.9, should be revised, excluding its lowest weights, which might be too thin.


The study did show that the two highest obesity categories (B.M.I. of 35 and up) are at high risk. “Once you have higher obesity, the fat’s in the fire,” Dr. Blackburn said.


But experts also suggested that concepts of fat be refined.


"Fat per se is not as bad as we thought," said Dr. Kamyar Kalantar-Zadeh, professor of Medicine and Public Health at the University of California, Irvine. "What is bad is a type of fat that is inside your belly. Non-belly fat, underneath your skin in your thigh and your butt area — these are not necessarily bad." He added that, to a point, extra fat is accompanied by extra muscle, which can be healthy.


Still, it is possible that overweight or somewhat obese people are less likely to die because they, or their doctors, have identified other conditions associated with weight gain, like high cholesterol or diabetes.


“You’re more likely to be in your doctor’s office and more likely to be treated,” said Dr. Robert Eckel, a past president of the American Heart Association and a professor at University of Colorado.


Some experts said fat could be protective in some cases, although that is unproven and debated. The study did find that people 65 and over had no greater mortality risk even at high obesity.


“There’s something about extra body fat when you’re older that is providing some reserve,” Dr. Eckel said.


And studies on specific illnesses, like heart and kidney disease, have found an “obesity paradox,” that heavier patients are less likely to die.


Still, death is not everything. Even if "being overweight doesn't increase your risk of dying," Dr. Klein said, it "does increase your risk of having diabetes" or other conditions.


Ultimately, said the study’s lead author, Katherine Flegal, a senior scientist at the Centers for Disease Control and Prevention, “the best weight might depend on the situation you’re in.”


Take the perfect woman, Elsie Scheel, in whose "physical makeup there is not a single defect," the Times article said. This woman who "has never been ill and doesn't know what fear is" loved sports and didn't consume candy, coffee or tea. But she also ate only three meals every two days, and loved beefsteak.


Maybe such seeming contradictions made sense against the societal inconsistencies of that time. After all, her post-college plans involved tilling her father’s farm, but “if she were a man, she would study mechanical engineering.”


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Optimistic stock investors reaped rewards worldwide in 2012









Wall Street closed out the year with a surge in the final trading session, betting on a last-minute resolution of the so-called fiscal cliff.


The market may have jumped the gun, but investors' hopefulness fit the pattern of 2012: It was a year of solid stock price gains worldwide, as various predictions of Armageddon fell flat.


That has reinforced many market pros' conventional cautious optimism as the new year begins. Bears can still find plenty to be dour about, but the bulls have called it right in three of the last four years since the 2008 financial-system crash.





On Monday, the Dow Jones industrial average jumped 166 points, or 1.3%, to end the year at 13,104. Stocks rallied late in the session as rumors spread that Congress would approve a deal to limit the tax increases and spending cuts otherwise set to kick in Tuesday.


But after the closing bell, a deal to avert the fiscal cliff appeared uncertain — raising fears of a blistering market sell-off Wednesday.


Still, investors who had expected a sustained slump in stocks in 2012 found themselves left behind as most world markets posted double-digit percentage gains, underpinned by a resilient U.S. economy and by central banks' efforts to keep interest rates at rock bottom.


Wall Street optimism about 2013 remains rooted in expectations that the U.S. economy will continue to expand, albeit slowly, and with it corporate earnings.


"Absent a complete failure from Washington, growth should remain positive," said Russ Koesterich, global chief investment strategist at money management giant BlackRock Inc. in New York.


That bet paid off in 2012: The Standard & Poor's 500 index, a popular benchmark for many Americans' retirement accounts, rose 1.7% to 1,426 on Monday and was up 13.4% for the year.


That was the biggest advance since the index rose 23.4% in 2009. Stocks' gains last year also beat returns on most kinds of bonds and on low-yielding short-term cash accounts.


The S&P index now has rebounded 111% from its decade low in March 2009, restoring most of the wealth lost by investors in the Great Recession — if they held on.


In Europe, the Stoxx index of 600 big-name shares rose 14.4% for the year, also the biggest rally since 2009. Japan's main market index soared 22.9%. Most so-called emerging markets also were up sharply, including those in India, Mexico and Turkey.


The 30-stock Dow index was a relative laggard, rising 7.3% for the year. It was hurt by weakness in major energy stocks as crude oil prices fell and by a collapse of shares of troubled tech giant Hewlett-Packard Co.


Markets worldwide had rallied in the first few months of 2012, then dived in spring as doubts multiplied about the global economy.


Europe, gripped for a third year by its government-debt crisis, was the epicenter of those fears: Many investors expected the Eurozone to finally break up under its debt strains, consigning Greece, Spain, Portugal and perhaps other nations to economic death spirals.


But the doomsday predictions were thwarted by the European Central Bank. In late July, ECB President Mario Draghi shocked markets by declaring that the central bank would do whatever was necessary to preserve the Eurozone. "And believe me, it will be enough," Draghi said.


The ECB followed that pledge with a commitment to buy unlimited sums of Eurozone governments' bonds, if necessary, to pull down countries' borrowing costs — similar to the U.S. Federal Reserve's ongoing program of buying Treasury debt.


The ECB's move sparked a sharp rally in the euro that buoyed confidence in European stocks as well, despite deep recessions in the Continent's hardest-hit economies.


The U.S. economy, meanwhile, confounded expectations that it would slide back into recession. The economy grew at a 3.1% annualized rate in the third quarter after slowing to a 1.3% rate in the second quarter. Growth was supported in part by the housing market's continuing rebound.


"Housing got us into this mess. Now it's one of the sectors to get us out," said Sam Stovall, chief investment strategist at S&P Capital IQ in New York.


Housing-related stocks were some of the year's biggest winners, with builder PulteGroup Inc. up 188%, appliance maker Whirlpool Corp. rising 114% and paint producer Sherwin-Williams Co. up 72%.


Worldwide, investors' confidence also benefited as worries dissipated about a war between Israel and Iran. And late in the year, hopes rose that China's slowing economy would avoid a so-called hard landing — which could have put it in a recession — and instead would help drive global growth in the new year. The Shanghai stock market rocketed nearly 15% in December alone.


Emerging markets such as China could be a big lure for global investors in 2013, some experts said. Many governments in those markets have more leeway than developed economies to bolster growth with fiscal stimulus measures and with lower interest rates, said Jack Ablin, chief investment officer at BMO Private Bank in Chicago.


By contrast, Ablin worries that U.S. economic growth and corporate earnings growth will be much slower than many investors are anticipating in the new year.


Whatever the ultimate workout of the fiscal cliff, Ablin said, "We are going to see taxes go up incrementally and spending go down incrementally," weighing on the economy.


Market pessimists believe that stock markets since 2009 have been driven largely by cheap credit supplied by central banks, particularly the Federal Reserve. Critics say the Fed's latest decision to ramp up purchases of Treasury bonds, aimed at pumping more money into the economy, smacks of desperation.


Fed Chairman Ben S. Bernanke, however, has insisted that the Fed still has plenty of tools left to help the U.S. recovery gain speed. Wall Street, by and large, believes Bernanke.


"If they can print money," Stovall said, "are the central banks ever really out of bullets?"


business@latimes.com





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Body of Connecticut shooter Adam Lanza quietly claimed by his father

Newtown, Conn. shooter Adam Lanza's body has been claimed by his father.









The body of Newtown, Conn., shooter Adam Lanza was claimed by his father last week, a family spokesman said Monday. 


Peter Lanza claimed his son's body from the Connecticut medical examiner last Thursday, said family spokesman Errol Cockfield.

“Private arrangements took place over the weekend," Cockfield said. He declined to elaborate further about the nature of the arrangements.


Connecticut Chief State Medical Examiner H. Wayne Carver, confirmed that Lanza's body is "finally gone."








Adam Lanza, 20, killed 20 first-graders and six adults at Sandy Hook Elementary School on Dec. 14 and then committed suicide. He also killed his mother in their Newtown home before the rampag.


PHOTOS: Connecticut school shooting

A private funeral was held earlier this month in New Hampshire for his mother, Nancy Lanza, who was divorced from Peter Lanza.


Authorities have not offered a motive for the killings. State police say they have been exploring all aspects of Adam Lanza's life, including his education, family history and medical treatment for clues.


"Our family is grieving along with all those who have been affected by this enormous tragedy," Peter Lanza said in a statement in the days after the shooting. "No words can truly express how heartbroken we are. We are in a state of disbelief and trying to find whatever answers we can. We too are asking why."


Peter Lanza lives in Stamford, Conn., and is an executive with GE Energy Financial Services. 


Adam Lanza, who was known to be very shy, had a tight relationship with his mother but was estranged from his father after the couple's 2001 separation was finalized in a 2009 divorce.


FULL COVERAGE: Shooting at Connecticut school



Adam Lanza also began refusing to see his brother, Ryan, an accountant in Manhattan, after their parents' 2009 divorce.


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Armstrong better, Green Day to resume tour in 2013


LOS ANGELES (AP) — Green Day is going back on the road.


The Grammy-winning punk band announced new tour dates Monday.


The band canceled the rest of its 2012 club schedule and postponed the start of a 2013 arena tour after singer-guitarist Billie Joe Armstrong's substance abuse problems emerged publicly in September when he had a profane meltdown on the stage of the iHeartRadio Music Festival in Las Vegas. The band's rep announced later that Armstrong was headed to treatment for substance abuse.


"I just want to thank you all for the love and support you've shown for the past few months," Armstrong told fans in a statement Monday. "Believe me, it hasn't gone unnoticed and I'm eternally grateful to have such an amazing set of friends and family. I'm getting better every day. So now, without further ado, the show must go on."


The tour is scheduled to begin March 28 at the Allstate Arena in the Chicago area. Tickets for postponed shows will be honored on the new dates, and refunds will be available for canceled shows.


"We want to thank everyone for hanging in with us for the last few months," the band said. "We are very excited to hit the road and see all of you again, though we regret having to cancel more shows."


The band released their most recent album, "Tre," on Dec. 11, more than a month ahead of schedule.


___


Online:


http://www.greenday.com/


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Essay: In Pursuit of Answers One May Not Want to Know

I jogged into the Stanford Cancer Clinic with my boyfriend, the youngest people there by two decades. We stood there sweating and holding hands, a jarring sight in the sickly light.

“You are 18, right?” the receptionist asked. Behind me, a woman so gaunt that her cheekbones protruded rolled by in a wheelchair. The oncologist called me alone to the exam room, and I told her the story I had revealed to more doctors than friends: I carry the BRCA1 mutation, which gives you a 98 percent chance of developing cancer.

When my family found out that I might have inherited the mutation from my mother, we took it as a given that I would get tested. Scientists, atheists and lawyers, we are compulsively rational. Yet when I learned I carried the mutation, I felt the cruel weight of a paradox: you can never know whether you want to know until you already do.

At Stanford, I study artificial intelligence, in which math is used to resolve these sorts of dilemmas. My teachers claim that gaining information never hurts. It can be proved mathematically that a robot with more information never makes worse decisions But we are not robots. Our eyes don’t filigree the world with coordinates and probabilities, and they can be blinded by tears.

Still, we, too, display a preference for information. We dislike uncertainty so strongly that we sometimes even prefer bad news. One study of people at risk for a terminal disease found that those who learned they were going to die from it were happier a year later than those who remained uncertain about their fates. Most people have a deep intuition that a life lived cleareyed has inherent value, independent of whether the truth makes you happy. But surely this has limits.

I know there are some things I do not want to know: which other girls my boyfriend finds attractive or the day and manner of my death. The truth can hurt in two ways. It can worsen your options: you can’t live as happily with a significant other after learning of his infidelity. Or it can make you irrational: hearing about terrorists targeting airplanes may lead you to drive instead of fly, though planes remain much safer than cars.

So was I wrong to unwind my double helix?

My risks of getting cancer at 21 are too low for me to do anything differently to better my odds. The knowledge is both irrelevant and painful; it’s obsessed me and made me behave irrationally. I wake from nightmares in which I am dying from cancer. I reread the memoirs of patients with metastatic disease until I can’t see the text through my tears. In my supposedly rational pursuit of knowledge, I’ve gone a little mad.

Despite an excess of information, I pursued more, enrolling in Stanford’s cancer biology class. The professor filled his slides with dark oncological puns, lecturing with the almost robotic detachment I sometimes see in those who work closely with cancer. Maybe I, too, am becoming robotic. I can laugh at the puns, calmly press lecturers on survival rates for breast cancer, marvel at the elegant molecular mechanisms by which it eats us alive. Just as tumors eventually swell too large for their hosts to endure, will all this knowledge grow past what I can handle?

The prospect was too much for my mother, a far tougher woman than I am. When she received a diagnosis of breast cancer, she ordered the doctors to give her chemotherapy as rapidly as possible and recovered completely. But she refused to learn her chances of long-term survival or look at her medical records. I became the first in my family to read them, and when I learned her cancer had been unusually lethal, my father asked me not to tell her.

I cannot shake the thought that this mutation was given to me for a reason. I don’t believe in God. I know my chromosomes divided along a random schism, not a divine skein. But while I reject the theist’s idea of God-granted purpose, I accept the existentialist’s idea of crafting your own. The world may be only sound and fury, but we can choose to see patterns in that chaos, stories in the stars.

So I choose to believe that I have been given this mutation so that I can discover how to overcome it. Like the protagonist in “Flowers for Algernon,” I will be both scientist and patient. Even if this sense of purpose is illusory, it lets me do what I couldn’t before. Fear has sharpened me: I wake at 3 in the morning to refine biological algorithms or to read papers on ovarian cancer.

While I believe this knowledge has made me live better, I am not sure it’s made me happier. True, there was the day I dropped by Stanford’s Relay for Life, a fund-raiser for cancer research, ran farther than I ever had and walked home full of joyful purpose. There was also the night I lost it completely and sobbed for hours in my boyfriend’s arms.

In this oscillation between light and dark, one thing remains constant: I’m no longer so eager to illuminate my fate. Recently, I went to the Web site of 23andMe, a company that will read from your genome your risk of dying from a hundred diseases. I clicked through the testimonials and was unnerved by how similar our reasons were for wanting information. I looked down at my fingertips, tempted: what else in my genome waits to be found?

But then I clicked away. The Bible doesn’t tell us if Eve ate any more apples, but I have had my fill of revelations. I am 21 years old, and I want to be free to live a normal life: fate unbound by double helix, future exploding with possibility. I don’t want to know.

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Stocks turn up on hints of `fiscal cliff' deal









The stock market shot higher on Monday afternoon, in the year's final hour of trading, signaling that investors believe the politicians in Washington will work out a budget compromise to avoid the “fiscal cliff.”

The Dow was up 137 to 13,075 in the late afternoon, more than 1 percent. The Standard & Poor's 500 and the Nasdaq composite were up by more, with the Nasdaq rising nearly 2 percent.

It was a high note in what had been a choppy day for the market, as choppy as the “fiscal cliff” deal-making that has been yanking it around.

Stocks opened lower and struggled for direction in the morning. They jerked higher at midday, on reports that the bare outline of a deal to avoid the “cliff” had been knit together. Then, they lost some of those gains when President Barack Obama made an early afternoon appearance to say that a compromise was “within sight,” but not finalized. Then, in the late afternoon, they shot higher.

The market's indecisiveness overlaid a day of dramatic budget negotiations in Washington. If Republicans and Democrats can't agree to a new budget deal by midnight, then higher taxes and lower government spending will automatically kick in Tuesday — the so-called fiscal cliff.

That would hurt the economy and could even send it back into recession, many investors believe. But what might hurt more, they add, is the psychological impact of knowing that the government can't agree on a budget.

“We're having a fragile recovery, with the pain of 2008 still fresh on everybody's mind,” said Joe Heider, principal at Rehmann Group outside Cleveland. “It's fear of the unknown. And fear is one of the greatest drivers of the financial markets.”

The Dow Jones industrial average surged 99 points in midday trading after The Associated Press reported that Republicans and Democrats had agreed on some key aspects of a compromise budget plan. They cooled after Obama made it clear that a deal wasn't done. Then, around 2:45 p.m. EST, they started shooting higher again.

Shortly after 3 p.m. EST, the Standard & Poor's 500 index was up 21 to 1,423 and the Nasdaq composite index was up 57 to 3,017.

Investors' opinions about the “fiscal cliff,” and how much it matters, are varied.

Some are unruffled: They're confident that politicians will work out a last-minute deal, as they often do. Or they think that even if the U.S. does go over the “cliff,” it would be more akin to the anti-climactic Y2K scare than a true Armageddon. The “cliff's” impact would be felt only gradually, they reason. For example, workers might get more taxes withheld from their first couple of paychecks in the new year, but it's not as if they'd have to pay all their higher taxes up front on Tuesday. And Congress could always retroactively repeal those higher taxes.

Others are more concerned. The higher taxes and lower government spending could take more than $600 billion out of the U.S. economy and send it back into recession. Politically, the U.S. would send a message that its lawmakers can't cooperate. And investors would have no good read on the country's long-term policy for taxes and spending, or how the government plans to eventually trim its deficit.

That's made the fiscal cliff's impact on the stock market uneven. From mid-November through roughly mid-December, the stock market rose more or less steadily, despite the “cliff” looming on the horizon. It wasn't until shortly before Christmas, with still no deal in sight, that the “cliff” finally scared investors enough to send the market down.

Tim Speiss, partner in charge of the personal wealth advisers practice at EisnerAmper in New York, followed the “cliff” negotiations on Monday and wondered if the U.S. would get its debt rating cut again. The Standard & Poor's ratings agency cut its rating of the U.S. government amid similar negotiations in August 2011, when lawmakers were arguing over the government's borrowing limit. S&P said at the time that the “political brinksmanship” highlighted how “America's governance and policymaking (is) becoming less stable, less effective, and less predictable.” Its rating cut sent the stock market into a tailspin.

The other major ratings agencies, Moody's and Fitch, have suggested that they might lower their ratings of the U.S. because of the “fiscal cliff.”

“That is, unfortunately, the big story,” Speiss said.

It's also one of the only stories. There's been little other news to trade on during the holiday season, giving the “fiscal cliff” drama outsized influence. No major companies are scheduled to report earnings this week. The most significant economic indicator scheduled for this week, the government's monthly jobs report, won't be released until Friday.

Trading volume has also been light, with many investors still on vacation. That also makes the market more volatile: With fewer shares trading hands, it can be moved by relatively small trades.

Last week, about 2.2 billion shares traded hands each day on average. Throughout the year, the average has been closer to 3.6 billion.

The yield on the benchmark 10-year Treasury note rose to 1.76 percent from 1.70 percent late Friday, a sign that investors were moving money into stocks.

Some of the best-performing stocks for the year were those that had been hammered in 2011. Homebuilder PulteGroup, appliance maker Whirlpool and Bank of America all more than doubled over the year, after falling by double-digit percentages in 2011.

Some of the worst performers of the year were Best Buy, Hewlett-Packard and J.C. Penney. All are struggling to keep up with competitors who have adapted more quickly to changing technologies and changing customer tastes. They were all up Monday, but were each down at least 45 percent for the year.

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Boehner: Obama won't stand up to his own party on 'fiscal cliff'









WASHINGTON -- House Speaker John A. Boehner called it “ironic” that President Obama blamed Republicans for stalled negotiations on the "fiscal cliff" and accused the Democrat of being unwilling to stand up to his own party.


Responding to Obama’s appearance on NBC’s “Meet The Press,” the Ohio Republican said the GOP has been “reasonable and responsible” throughout the talks.


“In an effort to get the president to agree to cut spending -- which is the problem -- I put revenues on the table last year, and I put them on the table again last month,” Boehner said in a statement. “Republicans made every effort to reach the ‘balanced’ deficit agreement that the president promised the American people, while the president has continued to insist on a package skewed dramatically in favor of higher taxes that would destroy jobs.”





In an interview taped Saturday, Obama told NBC’s David Gregory that he remained “optimistic” that a deal could be reached, but said that in his mind, the sticking point was that Republicans “have had trouble saying yes to a number of repeated offers.”


QUIZ: How much do you know about the fiscal cliff?


“Congress has not been able to get this stuff done, not because Democrats in Congress don't want to go ahead and cooperate, but because I think it's been very hard for Speaker Boehner and Republican Leader [Mitch] McConnell to accept the fact that taxes on the wealthiest Americans should go up a little bit, as part of an overall deficit reduction package,” he said.


“I negotiated with Speaker Boehner in good faith and moved more than halfway in order to achieve a grand bargain.”


Earlier this month, Obama had offered to raise the income threshold for higher tax rates to $400,000, from the $250,000 he had campaigned on. Boehner pulled back from the negotiations and tried to pass what he called "Plan B," which would have boosted the threshold to $1 million. He failed to get support from House Republicans and did not bring it to the floor.


Don Stewart, a spokesman for Senate Republican Leader Mitch McConnell, responded that “while the president was taping those discordant remarks yesterday, Sen. McConnell was in the office working to bring Republicans and Democrats together on a solution. Discussions continue today.”


In his statement, Boehner noted that the House has passed multiple bills that would avert the entire fiscal cliff, addressing both the looming across-the-board tax increases and deep spending cuts.


“The president has never called for the Senate to act on those bills in any way. He instead has simply allowed the Democratic-controlled Senate to sit on them and lead our economy to the edge of the fiscal cliff,” Boehner said.


PHOTOS: Notable moments of the 2012 presidential election


The Senate has passed budget bills that the House has not acted upon.


The House is due to gavel in Sunday afternoon, with votes expected on unrelated bills. The Senate is in session while leaders and staff continue to seek a solution that would garner enough votes to move over to the House.


“We know that there are negotiations going on,” Sen. Barbara Boxer (D-Calif.) said on the Senate floor. “I really hope our leaders can find a way out of this.”


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michael.memoli@latimes.com


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'The Hobbit' stays atop box office for third week


LOS ANGELES (AP) — "The Hobbit: An Unexpected Journey" continues to rule them all at the box office, staying on top for a third-straight week and capping a record-setting $10.8 billion year in moviegoing.


The Warner Bros. fantasy epic from director Peter Jackson, based on the beloved J.R.R. Tolkien novel, made nearly $33 million this weekend, according to Sunday studio estimates, despite serious competition from some much-anticipated newcomers. It's now made a whopping $686.7 million worldwide and $222.7 million domestically alone.


Two big holiday movies — and potential Academy Awards contenders — also had strong openings. Quentin Tarantino's spaghetti Western-blaxploitation mash-up "Django Unchained" came in second place for the weekend with $30.7 million. The Weinstein Co. revenge comedy, starring Jamie Foxx as a slave in the Civil War South and Christoph Waltz as the bounty hunter who frees him and then makes him his partner, has earned $64 million since its Christmas Day opening.


And in third place with $28 million was the sweeping, all-singing "Les Miserables," based on the international musical sensation and the Victor Hugo novel of strife and uprising in 19th century France. The Universal Pictures film, with a cast of A-list actors singing live on camera led by Hugh Jackman, Anne Hathaway and Russell Crowe has made $67.5 million domestically and $116.2 worldwide since debuting on Christmas.


Additionally, the smash-hit James Bond adventure "Skyfall" has now made $1 billion internationally to become the most successful film yet in the 50-year franchise, Sony Pictures announced Sunday. The film stars Daniel Craig for the third time as the iconic British superspy.


"This is a great final weekend of the year," said Paul Dergarabedian, an analyst for box-office tracker Hollywood.com. "How perfect to end this year on such a strong note with the top five films performing incredibly well."


The week's other new wide release, the Billy Crystal-Bette Midler comedy "Parental Guidance" from 20th Century Fox, made $14.8 million over the weekend for fourth place and $29.6 million total since opening on Christmas.


Dergarabedian described the holding power of "The Hobbit" in its third week as "just amazing." Jackson shot the film, the first of three prequels to his massively successful "Lord of the Rings" series, in 48 frames per second — double the normal frame rate — for a crisper, more detailed image. It's also available in the usual 24 frames per second and both 2-D and 3-D projections.


"I think people are catching up with the movie. Maybe they're seeing it in multiple formats," he said. "I think it's just a big epic that feels like a great way to end the moviegoing year. There's momentum there with this movie."


"Django Unchained" is just as much of an epic in its own stylishly violent way that's quintessentially Tarantino. Erik Lomis, The Weinstein Co.'s president of theatrical distribution, said the opening exceeded the studio's expectations.


"We're thrilled with it, clearly. We knew it was extremely competitive at Christmas, particularly when you look at the start 'Les Miz' got. We were sort of resigned to being behind them. The fact that we were able to overtake them over the weekend was just great," Lomis said. "Taking nothing away from their number, it's a tribute to the playability of 'Django.'"


"Les Miserables" went into its opening weekend with nearly $40 million in North American grosses, including $18.2 on Christmas Day. That's the second-best opening ever on the holiday following "Sherlock Holmes," which made $24.9 million on Christmas 2009. Tom Hooper, in a follow-up to his Oscar-winner "The King's Speech," directs an enormous, ambitious take on the beloved musical which has earned a CinemaScore of "A'' from audiences and "A-plus" from women.


Nikki Rocco, Universal's head of distribution, said the debut for "Les Miserables" also beat the studio's expectations.


"That $18.2 million Christmas Day opening — people were shocked ... This is a musical!" she said. "Once people see it, they talk about how fabulous it is."


It all adds up to a record-setting year at the movies, beating the previous annual record of $10.6 billion set in 2009. Dergarabedian pointed out that the hits came scattered throughout the year, not just during the summer blockbuster season or prestige-picture time at the end. "Contraband," ''Safe House" and "The Vow" all performed well early on, but then when the big movies came, they were huge. "The Avengers" had the biggest opening ever with $207.4 million in May. The raunchy comedy "Ted" and comic-book behemoth "The Dark Knight Rises" both found enormous audiences. And Paul Thomas Anderson's challenging drama "The Master" shattered records in September when it opened on five screens in New York and Los Angeles with $736,311, for a staggering per-screen average of $147,262.


"We were able to get this record without scratching and clawing to a record," he said.


Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Hollywood.com. Where available, latest international numbers are also included. Final domestic figures will be released Monday.


1. "The Hobbit: An Unexpected Journey," $32.9 million ($106.5 million international).


2."Django Unchained," $30.7 million.


3."Les Miserables," $28 million ($38.3 million international).


4."Parental Guidance," $14.8 million ($7 million international).


5."Jack Reacher," $14 million ($18.1 million).


6."This Is 40," $13.2 million.


7."Lincoln," $7.5 million.


8."The Guilt Trip," $6.7 million.


9."Monsters, Inc. 3-D," $6.4 million.


10."Rise of the Guardians," $4.9 million ($11.6 million).


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Estimated weekend ticket sales at international theaters (excluding the U.S. and Canada) for films distributed overseas by Hollywood studios, according to Rentrak:


1."The Hobbit: An Unexpected Journey," $106.5 million.


2."Life of Pi," $39.2 million.


3."Les Miserables," $38.3 million.


4."Wreck-It Ralph," $20.4 million.


5."Jack Reacher," $18.1 million.


6."Rise of the Guardians," $11.6 million.


7."Parental Guidance," $7 million.


8."The Tower," $6.6 million.


9."Pitch Perfect," $6.2 million.


10."De L'autre Cote Du Periph," $4 million.


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Online:


http://www.hollywood.com


http://www.rentrak.com


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Universal and Focus are owned by NBC Universal, a unit of Comcast Corp.; Sony, Columbia, Sony Screen Gems and Sony Pictures Classics are units of Sony Corp.; Paramount is owned by Viacom Inc.; Disney, Pixar and Marvel are owned by The Walt Disney Co.; Miramax is owned by Filmyard Holdings LLC; 20th Century Fox and Fox Searchlight are owned by News Corp.; Warner Bros. and New Line are units of Time Warner Inc.; MGM is owned by a group of former creditors including Highland Capital, Anchorage Advisors and Carl Icahn; Lionsgate is owned by Lions Gate Entertainment Corp.; IFC is owned by AMC Networks Inc.; Rogue is owned by Relativity Media LLC.


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Well: Exercise and the Ever-Smarter Human Brain

Anyone whose resolve to exercise in 2013 is a bit shaky might want to consider an emerging scientific view of human evolution. It suggests that we are clever today in part because a million years ago, we could outrun and outwalk most other mammals over long distances. Our brains were shaped and sharpened by movement, the idea goes, and we continue to require regular physical activity in order for our brains to function optimally.

Phys Ed

Gretchen Reynolds on the science of fitness.

The role of physical endurance in shaping humankind has intrigued anthropologists and gripped the popular imagination for some time. In 2004, the evolutionary biologists Daniel E. Lieberman of Harvard and Dennis M. Bramble of the University of Utah published a seminal article in the journal Nature titled “Endurance Running and the Evolution of Homo,” in which they posited that our bipedal ancestors survived by becoming endurance athletes, able to bring down swifter prey through sheer doggedness, jogging and plodding along behind them until the animals dropped.

Endurance produced meals, which provided energy for mating, which meant that adept early joggers passed along their genes. In this way, natural selection drove early humans to become even more athletic, Dr. Lieberman and other scientists have written, their bodies developing longer legs, shorter toes, less hair and complicated inner-ear mechanisms to maintain balance and stability during upright ambulation. Movement shaped the human body.

But simultaneously, in a development that until recently many scientists viewed as unrelated, humans were becoming smarter. Their brains were increasing rapidly in size.

Today, humans have a brain that is about three times larger than would be expected, anthropologists say, given our species’ body size in comparison with that of other mammals.

To explain those outsized brains, evolutionary scientists have pointed to such occurrences as meat eating and, perhaps most determinatively, our early ancestors’ need for social interaction. Early humans had to plan and execute hunts as a group, which required complicated thinking patterns and, it’s been thought, rewarded the social and brainy with evolutionary success. According to that hypothesis, the evolution of the brain was driven by the need to think.

But now some scientists are suggesting that physical activity also played a critical role in making our brains larger.

To reach that conclusion, anthropologists began by looking at existing data about brain size and endurance capacity in a variety of mammals, including dogs, guinea pigs, foxes, mice, wolves, rats, civet cats, antelope, mongooses, goats, sheep and elands. They found a notable pattern. Species like dogs and rats that had a high innate endurance capacity, which presumably had evolved over millenniums, also had large brain volumes relative to their body size.

The researchers also looked at recent experiments in which mice and rats were systematically bred to be marathon runners. Lab animals that willingly put in the most miles on running wheels were interbred, resulting in the creation of a line of lab animals that excelled at running.

Interestingly, after multiple generations, these animals began to develop innately high levels of substances that promote tissue growth and health, including a protein called brain-derived neurotrophic factor, or BDNF. These substances are important for endurance performance. They also are known to drive brain growth.

What all of this means, says David A. Raichlen, an anthropologist at the University of Arizona and an author of a new article about the evolution of human brains appearing in the January issue of Proceedings of the Royal Society Biology, is that physical activity may have helped to make early humans smarter.

“We think that what happened” in our early hunter-gatherer ancestors, he says, is that the more athletic and active survived and, as with the lab mice, passed along physiological characteristics that improved their endurance, including elevated levels of BDNF. Eventually, these early athletes had enough BDNF coursing through their bodies that some could migrate from the muscles to the brain, where it nudged the growth of brain tissue.

Those particular early humans then applied their growing ability to think and reason toward better tracking prey, becoming the best-fed and most successful from an evolutionary standpoint. Being in motion made them smarter, and being smarter now allowed them to move more efficiently.

And out of all of this came, eventually, an ability to understand higher math and invent iPads. But that was some time later.

The broad point of this new notion is that if physical activity helped to mold the structure of our brains, then it most likely remains essential to brain health today, says John D. Polk, an associate professor of anthropology at the University of Illinois at Urbana-Champaign, and co-author, with Dr. Raichlen, of the new article.

And there is scientific support for that idea. Recent studies have shown, he says, that “regular exercise, even walking,” leads to more robust mental abilities, “beginning in childhood and continuing into old age.”

Of course, the hypothesis that jogging after prey helped to drive human brain evolution is just a hypothesis, Dr. Raichlen says, and almost unprovable.

But it is compelling, says Harvard’s Dr. Lieberman, who has worked with the authors of the new article. “I fundamentally agree that there is a deep evolutionary basis for the relationship between a healthy body and a healthy mind,” he says, a relationship that makes the term “jogging your memory” more literal than most of us might have expected and provides a powerful incentive to be active in 2013.

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Obama blames GOP for 'fiscal cliff' brinksmanship









WASHINGTON -- President Obama blamed Republican leaders for the latest round of brinkmanship in Washington and said it was now up to lawmakers to find a way back from the so-called fiscal cliff.


In an interview with NBC’s “Meet the Press” aired Sunday, Obama said he had reached out to Republicans for weeks, but their refusal to raise taxes had blocked progress.


“They have had trouble saying yes to a number of repeated offers,” Obama said. In Friday’s meeting with congressional leaders at the White House, “I suggested to them if they can't do a comprehensive package of smart deficit reductions, let's at minimum make sure that people's taxes don't go up and that 2 million people don't lose their unemployment insurance.





“And I was modestly optimistic yesterday,” he added in the interview taped Saturday, referring to the aftermath of that meeting, “but we don't yet see an agreement. And now the pressure's on Congress to produce.”


PHOTOS: Notable moments of the 2012 presidential election


Senate leaders and their aides spent Saturday working on a deal that would protect most taxpayers from seeing their incomes taxes rise Jan. 1. The deal may also set new estate tax rates, prevent an expansion of the alternative minimum tax and extend unemployment insurance.


If the effort is successful, a final proposal is expected later Sunday, when senators are set to meet in party caucuses.


A spokesman for Senate Minority Leader Mitch McConnell responded to the president's criticism:


"While the president was taping those discordant remarks yesterday, Sen. McConnell was in the office working to bring Republicans and Democrats together on a solution," Don Stewart said. "Discussions continue today."


In the interview, Obama said he expected an “adverse reaction in the markets” and depressed consumer spending if lawmakers allow the tax increase to take effect as scheduled -- and he tried to lay the blame on Republicans. Economists have suggested the combination of the tax increases, along with nearly $65 billion in spending cuts, could knock the economy back into a recession.


Obama did not offer a clear strategy for avoiding those spending cuts, which Congress and the president agreed to in 2011 as a way to force themselves to act on a larger deficit reduction deal. That deal has remained elusive, and Obama said in the interview that Republicans have had trouble saying yes to his offers.


QUIZ: How much do you know about the fiscal cliff?


Pressed by host David Gregory on why that is, Obama answered:


“That's something you're probably going to have to ask them, because, David, you follow this stuff pretty carefully. The offers that I’ve made to them have been so fair that a lot of Democrats get mad at me. I mean, I offered to make some significant changes to our entitlement programs in order to reduce the deficit,” he said, referring specifically to a change in the way Social Security cost of living increases are calculated, which many liberal groups opposed.


“They say that their biggest priority is making sure that we deal with the deficit in a serious way, but the way they're behaving is that their only priority is making sure that tax breaks for the wealthiest Americans are protected. That seems to be their only overriding, unifying theme.”


Obama has tried to frame the debate as a battle over taxes. One Republican acknowledged Sunday that the president appears poised to win the political battle on that front. If lawmakers agree on allowing taxes to rise on top earners, “it will accomplish a political victory for the president,” said Sen. Lindsey Graham of South Carolina


“Hats off to the president. He stood his ground; he’s going to get tax rate increases … on upper income Americans. And the sad news for the country is we’ve accomplished very little in terms of not becoming Greece or getting out of debt.… Hats off to the president -- he won.”


[For the Record, 8:05 a.m. PST  Dec. 30: This post has been updated to include reactions to Obama's comments from McConnell's office.]


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